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1

Isocyanate-Free Curing of Glycidyl Azide Polymer (GAP) with Bis-Propargyl-Succinate (II)

Thomas Keicher, Werner Kuglstatter, Siegfried Eisele, Tim Wetzel, Horst Krause

Journal:

Propellants, Explosives, Pyrotechnics

Year:

2009

Language:

english

File:

PDF, 187 KB

english, 2009

2

Bruton’s Tyrosine Kinase Inhibitors: Approaches to Potent and Selective Inhibition, Preclinical and Clinical Evaluation for Inflammatory Diseases and B Cell Malignancies

Lou, Yan, Owens, Timothy D., Kuglstatter, Andreas, Kondru, Rama K., Goldstein, David M.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.94 MB

english, 2012

3

Class, Lifestyle and Substance Use among Adolescents: A Bourdieusian Perspective

Skrobanek, Jan, Kuglstatter, Verena

Journal:

Year:

2018

Language:

english

File:

PDF, 890 KB

english, 2018

4

Rational Design of Highly Selective Spleen Tyrosine Kinase Inhibitors

Lucas, Matthew C., Goldstein, David M., Hermann, Johannes C., Kuglstatter, Andreas, Liu, Wenjian, Luk, Kin Chun, Padilla, Fernando, Slade, Michelle, Villaseñor, Armando G., Wanner, Jutta, Xie, Wenwei,

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 4.43 MB

english, 2012

5

Pyrrolopyrazines as Selective Spleen Tyrosine Kinase Inhibitors

Padilla, Fernando, Bhagirath, Niala, Chen, Shaoqing, Chiao, Eric, Goldstein, David M., Hermann, Johannes C., Hsu, Jonathan, Kennedy-Smith, Joshua J., Kuglstatter, Andreas, Liao, Cheng, Liu, Wenjian, L

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.47 MB

english, 2013

6

Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: Amide⋅⋅⋅Heteroarene π-Stacking Interactions and Chalcogen Bonding in the S3 Pocket

Giroud, Maude, Ivkovic, Jakov, Martignoni, Mara, Fleuti, Marianne, Trapp, Nils, Haap, Wolfgang, Kuglstatter, Andreas, Benz, Jörg, Kuhn, Bernd, Schirmeister, Tanja, Diederich, François

Journal:

Year:

2017

Language:

english

File:

PDF, 13.46 MB

english, 2017

7

Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors

Giroud, Maude, Dietzel, Uwe, Anselm, Lilli, Banner, David, Kuglstatter, Andreas, Benz, Jörg, Blanc, Jean-Baptiste, Gaufreteau, Delphine, Liu, Haixia, Lin, Xianfeng, Stich, August, Kuhn, Bernd, Schuler

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 3.36 MB

english, 2018

8

Tyramine fragment binding to BACE-1

Andreas Kuglstatter, Martin Stahl, Jens-Uwe Peters, Walter Huber, Martine Stihle, Daniel Schlatter, Jörg Benz, Armin Ruf, Doris Roth, Thilo Enderle, Michael Hennig

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 731 KB

english, 2008

9

X-ray crystal structure of JNK2 complexed with the p38α inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors

Andreas Kuglstatter, Manjiri Ghate, Stan Tsing, Armando G. Villaseñor, David Shaw, Jim W. Barnett, Michelle F. Browner

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 669 KB

english, 2010

10

Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures

Andreas Kuglstatter, April Wong, Stan Tsing, Simon W. Lee, Yan Lou, Armando G. Villaseñor, J. Michael Bradshaw, David Shaw, Jim W. Barnett, Michelle F. Browner

Journal:

Protein Science

Year:

2011

Language:

english

File:

PDF, 463 KB

english, 2011

11

The activation energies of crystallization in the amorphous alloy METGLAS®2826A

M. von Heimendahl, G. Kuglstatter

Journal:

Journal of Materials Science

Year:

1981

Language:

english

File:

PDF, 540 KB

english, 1981

12

Structural Insights for Design of Potent Spleen Tyrosine Kinase Inhibitors from Crystallographic Analysis of Three Inhibitor Complexes

Armando G. Villaseñor, Rama Kondru, Hoangdung Ho, Sandra Wang, Eva Papp, David Shaw, Jim W. Barnett, Michelle F. Browner, Andreas Kuglstatter

Journal:

Chemical Biology & Drug Design

Year:

2009

Language:

english

File:

PDF, 368 KB

english, 2009

13

Reply to "Complex conformations and crystal contacts"

Oubridge, Chris, Isel, Catherine, Kuglstatter, Andreas, Nagai, Kiyoshi

Journal:

Natural Structural Biology

Year:

2003

Language:

english

File:

PDF, 527 KB

english, 2003

14

Induced structural changes of 7SL RNA during the assembly of human signal recognition particle

Kuglstatter, Andreas, Oubridge, Chris, Nagai, Kiyoshi

Journal:

Natural Structural Biology

Year:

2002

Language:

english

File:

PDF, 1.10 MB

english, 2002

15

Discovery of 6-(2,4-Difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (Pamapimod) and 6-(2,4-Difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as Orally Bioavailable and Highly Selective Inhibitors of p38α Mitogen-Activated Protein Kinase

Goldstein, David M., Soth, Michael, Gabriel, Tobias, Dewdney, Nolan, Kuglstatter, Andreas, Arzeno, Humberto, Chen, Jeffrey, Bingenheimer, William, Dalrymple, Stacie A., Dunn, James

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.29 MB

english, 2011

16

The Crystal Structure of JNK2 Reveals Conformational Flexibility in the MAP Kinase Insert and Indicates Its Involvement in the Regulation of Catalytic Activity

David Shaw, Sandra M. Wang, Armando G. Villaseñor, Stan Tsing, David Walter, Michelle F. Browner, Jim Barnett, Andreas Kuglstatter

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 912 KB

english, 2008

17

Structure of the photosynthetic reaction centre from Rhodobacter sphaeroides reconstituted with anthraquinone as primary quinone QA

Andreas Kuglstatter, Jaroslava Miksovska, Pierre Sebban, Günter Fritzsch

Journal:

Year:

2000

Language:

english

File:

PDF, 252 KB

english, 2000

18

Corrigendum to: Identification of a hydrogen bond in the Phe-M197→Tyr mutant reaction center of the photosynthetic purple bacterium Rhodobacter sphaeroides by X-ray crystallography and FTIR spectroscopy (FEBS 23044): [FEBS Letters 463 (1999) 169–174]

Andreas Kuglstatter, Petra Hellwig, Günter Fritzsch, Josef Wachtveitl, Dieter Oesterhelt, Werner Mäntele, Hartmut Michel

Journal:

Year:

2000

Language:

english

File:

PDF, 35 KB

english, 2000

19

Identification of a hydrogen bond in the Phe M197→Tyr mutant reaction center of the photosynthetic purple bacterium Rhodobacter sphaeroides by X-ray crystallography and FTIR spectroscopy

Andreas Kuglstatter, Petra Hellwig, Günter Fritzsch, Josef Wachtveitl, Dieter Oesterhelt, Werner Mäntele, Hartmut Michel

Journal:

Year:

1999

Language:

english

File:

PDF, 245 KB

english, 1999

20

Crystal Structure of SRP19 in Complex with the S Domain of SRP RNA and Its Implication for the Assembly of the Signal Recognition Particle

Chris Oubridge, Andreas Kuglstatter, Luca Jovine, Kiyoshi Nagai

Journal:

Year:

2002

Language:

english

File:

PDF, 1.05 MB

english, 2002

21

Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors

Jaime-Figueroa, Saul, De Vicente, Javier, Hermann, Johannes, Jahangir, Alam, Jin, Sue, Kuglstatter, Andreas, Lynch, Stephen M., Menke, John, Niu, Linghao, Patel, Vaishali, Shao, Ada, Soth, Michael, Vu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1017 KB

english, 2013

22

Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome

Lynch, Stephen M., DeVicente, Javier, Hermann, Johannes C., Jaime-Figueroa, Saul, Jin, Sue, Kuglstatter, Andreas, Li, Hongju, Lovey, Allen, Menke, John, Niu, Linghao, Patel, Vaishali, Roy, Douglas, So

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 3.07 MB

english, 2013

23

Identification of Potent and Selective Cathepsin S Inhibitors Containing Different Central Cyclic Scaffolds

Hilpert, Hans, Mauser, Harald, Humm, Roland, Anselm, Lilli, Kuehne, Holger, Hartmann, Guido, Gruener, Sabine, Banner, David W., Benz, Joerg, Gsell, Bernard, Kuglstatter, Andreas, Stihle, Martine, Thom

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.89 MB

english, 2013

24

Structure-Based Drug Design of RN486, a Potent and Selective Bruton’s Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis

Lou, Yan, Han, Xiaochun, Kuglstatter, Andreas, Kondru, Rama K., Sweeney, Zachary K., Soth, Michael, McIntosh, Joel, Litman, Renee, Suh, Judy, Kocer, Buelent, Davis, Dana, Park, Jaehyeon, Frauchiger, S

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 426 KB

english, 2015

25

Selective p38α Inhibitors Clinically Evaluated for the Treatment of Chronic Inflammatory Disorders

Goldstein, David M., Kuglstatter, Andreas, Lou, Yan, Soth, Michael J.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 3.97 MB

english, 2010

26

X-ray Structure Analyses of Photosynthetic Reaction Center Variants from Rhodobacter sphaeroides : Structural Changes Induced by Point Mutations at Position L209 Modulate Electron and Proton Transfer †

Kuglstatter, Andreas, Ermler, Ulrich, Michel, Hartmut, Baciou, Laura, Fritzsch, Günter

Journal:

Year:

2001

Language:

english

File:

PDF, 711 KB

english, 2001

27

Using Ovality to Predict Nonmutagenic, Orally Efficacious Pyridazine Amides as Cell Specific Spleen Tyrosine Kinase Inhibitors

Lucas, Matthew C., Bhagirath, Niala, Chiao, Eric, Goldstein, David M., Hermann, Johannes C., Hsu, Pei-Yuan, Kirchner, Stephan, Kennedy-Smith, Joshua J., Kuglstatter, Andreas, Lukacs, Christine, Menke,

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 441 KB

english, 2014

28

Scaffold hopping towards potent and selective JAK3 inhibitors: Discovery of novel C-5 substituted pyrrolopyrazines

de Vicente, Javier, Lemoine, Remy, Bartlett, Mark, Hermann, Johannes C., Hekmat-Nejad, Mohammad, Henningsen, Robert, Jin, Sue, Kuglstatter, Andreas, Li, Hongju, Lovey, Allen J., Menke, John, Niu, Ling

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.15 MB

english, 2014

29

Finding the perfect spot for fluorine: Improving potency up to 40-fold during a rational fluorine scan of a Bruton’s Tyrosine Kinase (BTK) inhibitor scaffold

Lou, Yan, Sweeney, Zachary K., Kuglstatter, Andreas, Davis, Dana, Goldstein, David M., Han, Xiaochun, Hong, Junbae, Kocer, Buelent, Kondru, Rama K., Litman, Renee, McIntosh, Joel, Sarma, Keshab, Suh,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.02 MB

english, 2015

30

Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations

Kuglstatter, A., Villasenor, A. G., Shaw, D., Lee, S. W., Tsing, S., Niu, L., Song, K. W., Barnett, J. W., Browner, M. F.

Journal:

The Journal of Immunology

Year:

2007

Language:

english

File:

PDF, 1006 KB

english, 2007

31

Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys

Martin, Rainer E., Aebi, Johannes D., Hornsperger, Benoit, Krebs, Hans-Jakob, Kuhn, Bernd, Kuglstatter, Andreas, Alker, André M., Märki, Hans Peter, Müller, Stephan, Burger, Dominique, Ottaviani, Gior

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 2.80 MB

english, 2015

32

Kernspintomographie der Lunatummalazie

M. Nägele, W. Kuglstatter, D. Hahn, K. Wilhelm

Year:

1988

Language:

german

File:

PDF, 928 KB

german, 1988

33

VH-VL orientation prediction for antibody humanization candidate selection: A case study

Bujotzek, Alexander, Lipsmeier, Florian, Harris, Seth F., Benz, Jörg, Kuglstatter, Andreas, Georges, Guy

Journal:

Year:

2015

Language:

english

File:

PDF, 3.95 MB

english, 2015

34

A Real-World Perspective on Molecular Design

Kuhn, Bernd, Guba, Wolfgang, Hert, Jérôme, Banner, David W., Bissantz, Caterina, Ceccarelli, Simona Maria, Haap, Wolfgang, Körner, Matthias, Kuglstatter, Andreas, Lerner, Christian D., Mattei, Patrizi

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 2.18 MB

english, 2016

35

Kernspintomographie der Skaphoidpseudarthrose: Klinische und röntgenologische Gesichtspunkte

Nägele, M., Schade, G., Kuglstatter, W., Wilhelm, K., Lienemann, A., Gamarra, F., Lumper, W., Hahn, D.

Journal:

RöFo - Fortschritte auf dem Gebiet der R

Year:

1990

Language:

german

File:

PDF, 897 KB

german, 1990

36

Structure and Assembly of the Spliceosomal snRNPs

Nagai, K., Muto, Y., Pomeranz Krummel, D.A., Kambach, C., Ignjatovic, T., Walke, S., Kuglstatter, A.

Journal:

Biochemical Society Transactions

Year:

2001

Language:

english

File:

PDF, 1.10 MB

english, 2001

37

Structure and Assembly of the Spliceosomal snRNPs

Nagai, K., Muto, Y., Krummel, D. A. Pomeranz, Kambach, C., Ignjatovic, T., Walke, S., Kuglstatter, A.

Journal:

Biochemical Society Transactions

Year:

2001

Language:

english

File:

PDF, 1.10 MB

english, 2001

38

Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors

Kuhn, Bernd, Tichý, Michal, Wang, Lingle, Robinson, Shaughnessy, Martin, Rainer E., Kuglstatter, Andreas, Benz, Jörg, Giroud, Maude, Schirmeister, Tanja, Abel, Robert, Diederich, François, Hert, Jérôm

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 3.41 MB

english, 2017

39

Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport

Ruderisch, Nadine, Schlatter, Daniel, Kuglstatter, Andreas, Guba, Wolfgang, Huber, Sylwia, Cusulin, Carlo, Benz, Jörg, Rufer, Arne Christian, Hoernschemeyer, Joerg, Schweitzer, Christophe, Bülau, Tina

Journal:

Year:

2017

Language:

english

File:

PDF, 2.16 MB

english, 2017

40

Structure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies

Nelson, Bryce, Adams, Jarrett, Kuglstatter, Andreas, Li, Zhijian, Harris, Seth F., Liu, Yang, Bohini, Sandya, Ma, Han, Klumpp, Klaus, Gao, Junjun, Sidhu, Sachdev S.

Journal:

Journal of Molecular Biology

Year:

2018

Language:

english

File:

PDF, 10.30 MB

english, 2018

41

Water molecules in protein–ligand interfaces. Evaluation of software tools and SAR comparison

Nittinger, Eva, Gibbons, Paul, Eigenbrot, Charles, Davies, Doug R., Maurer, Brigitte, Yu, Christine L., Kiefer, James R., Kuglstatter, Andreas, Murray, Jeremy, Ortwine, Daniel F., Tang, Yong, Tsui, Vi

Journal:

Journal of Computer-Aided Molecular Design

Year:

2019

File:

PDF, 3.79 MB

2019

42

Water molecules in protein–ligand interfaces. Evaluation of software tools and SAR comparison

Nittinger, Eva, Gibbons, Paul, Eigenbrot, Charles, Davies, Doug R., Maurer, Brigitte, Yu, Christine L., Kiefer, James R., Kuglstatter, Andreas, Murray, Jeremy, Ortwine, Daniel F., Tang, Yong, Tsui, Vi

Journal:

Journal of Computer-Aided Molecular Design

Year:

2019

Language:

english

File:

PDF, 3.79 MB

english, 2019

43

A potent seven-membered cyclic BTK (Bruton's tyrosine Kinase) chiral inhibitor conceived by structure-based drug design to lock its bioactive conformation

Lopez-Tapia, Francisco, Lou, Yan, Brotherton-Pleiss, Christine, Kuglstatter, Andreas, So, Sung-Sau, Kondru, Rama

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2019

File:

PDF, 998 KB

2019

44

Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Liu, Yongfu, Wu, Jun, Zhou, Mingwei, Chen, Wenming, Li, Dongbo, Wang, Zhan-Guo, Hornsperger, Benoit, Aebi, Johannes D., MÃ¤rki, Hans-Peter, Kuhn, Bernd, Wang, Lisha, Kuglstatter, Andreas, Benz, JÃ¶rg,

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.11 MB

2020

45

Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices

Dengl, Stefan, Mayer, Klaus, Bormann, Felix, Duerr, Harald, Hoffmann, Eike, Nussbaum, Bianca, Tischler, Michael, Wagner, Martina, Kuglstatter, Andreas, Leibrock, Lea, Buldun, Can, Georges, Guy, Brinkm

Journal:

Nature Communications

Year:

2020

File:

PDF, 1.73 MB

2020